Figure 4.

Continuous progressive aerobic exercise (CP AE) modulates gene expression of synaptic-related genes in frontal cortex (FC). Histograms reporting gene expression analysis of Cdc42, Shank3, Robo2, and Nestin analyzed by RT-qPCR on RNA extracted from (A) hippocampus and (B) FC of the sedentary (n = 5) and the CP-trained mice (n = 5). CP protocol upregulates (Cdc42 p = 0.0153; Shank3 p = 0.0417; Robo2 p = 0.0177) these genes with respect to the sedentary animals in FC and not in hippocampus. Nestin is not modulated after CP training. β-actin is used as reference gene. (* p < 0.05). Error bars represent SD. Solid circle: sedentary mice. Solid square: trained mice.