Fig. 1.

Analysis of arterial plasma after intravenous injection of [¹¹C]PS13 in 10 healthy human individuals. (A) Reversed phase radio high-performance liquid chromatography (HPLC) analysis of plasma at 60 min in a participant. At least six radiometabolites were detected; A = 10.5%; B = 14.5%; C = 5%; D = 12.1%; E = 0.4%; Parent = 57.4%; F = 0.1%. (B) Change of plasma parent fraction over time. (C) Plasma parent concentration during the earliest 3 min after injection. (D) Plasma parent concentration from 3 min post-injection. Data are mean ± SD in B and D, and mean in C, where the SD was not displayed for the sake of clarity. SUV, standardized uptake value