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. 2021 Jul 6;9(7):e003019. doi: 10.1136/jitc-2021-003019

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Activated CD4+ (left column) or CD8+ (right column) T cells broken out by hTERT dose, IL-12 dose and cancer type. (A–C) Open symbols represent individual patients, the mean is represented with ‘+’, the box extends from the 25 th to the 75 th percentile, line inside the box is a the median, and the whiskers extend from the minimum to maximum values. Wilcoxon signs RANK test was used to assess significance between the magnitude of IFN-g in patients before (PRE) and after (POST) immunotherapy. The number and percent of patients in each group that had an increase, decrease or no change from baseline is displayed below each graph. hTERT, human telomerase reverse transcriptase; IFN-g, interferon-γ; IL-12, interleukin 12.