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. 2021 Jul 6;9(7):e003019. doi: 10.1136/jitc-2021-003019

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Activated CD8 +T cells with lytic potential broken out by hTERT dose, IL-12 dose and cancer type. (A) Representative dot plot showing CD8 +T cells expressing the activation marker CD38 and lytic granules—perforin, granzyme A and granzyme B. (B, C) Open symbols represent individual patients, the mean is represented with ‘+’, the box extends from 25 th to 75 th percentile, line inside the box is a the median, and the whiskers extend from the minimum to maximum values. Wilcoxon signs rank test was used to assess significance between the magnitude of IFN-g in patients before (PRE) and after (POST) immunotherapy. The number and per cent of patients in each group that had an increase, decrease or no change from baseline is displayed below each graph. hTERT, human telomerase reverse transcriptase; IFN, interferon; IL-12, interleukin.