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. 2021 Jul 6;11(7):e042857. doi: 10.1136/bmjopen-2020-042857

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Timeline of measurements of BChE and AChE: blood samples were taken 1 day preoperative (D O), shortly before anaesthetic induction (D 1), on admission to ICU (POD 0), 1 day after surgery (POD 1) and 2 days after surgery (POD 2). If the measuremnets could not be conducted immediatley, the samples have been cooled in a refrigerator and the measurement was performed up to 2 hours later. AChE, acetylcholinesterase; BChE, butyrylcholinesterase; ICU, intensive care unit, POD, Postoperative Day.