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. Author manuscript; available in PMC: 2021 Jul 7.
Published in final edited form as: Neurochem Int. 2018 Jul 24;123:22–33. doi: 10.1016/j.neuint.2018.07.009

Table 1.

Total amino acids in the cerebral cortex (including hippocampus) from cortical Glul knockouts and wildtype littermates

  Cortex Cerebellum
WT (Cre-; GSf/?) cKO (Cre+; GSf/f) WT (Cre-; GSf/?) cKO (Cre+; GSf/f)
Asp 2.86 ± 0.52 0.86 ± 0.19* 2.24 ± 0.36 2.38 ± 0.31
Glu 9.45 ± 1.76 4.82 ±0.52* 8.17 ± 0.33 8.58 ± 0.59
Gln 4.39 ± 0.24 1.05 ± 0.25* 4.81 ± 0.30 4.90 ± 1.17
Tau 10.20 ± 2.87 12.43 ± 0.89 6.09 ± 0.13 7.46 ± 0.79
Ala 0.84 ± 0.16 0.93 ± 0.10 0.25 ± 0.17 0.30 ± 0.12
GABA 1.55 ± 0.48 0.82 ± 0.18* 1.08 ± 0.36 1.08 ± 0.03

Amino acid concentrations (nmol per mg wet weight of whole tissue) were determined by means of HPLC in samples from three conditional Glul cortical knockouts (cKO) and two wildtype littermates. The mice, all females, were about 8 weeks old. The cortex samples comprised the entire neocortex and hippocampus. The numbers represent mean ± SD