Table 2.
Clinicopathological characteristics of patients stratified by pre-CRT LCR
| Characteristic | LCR low (n = 24) |
LCR high (n = 24) |
P value |
|---|---|---|---|
| Age (years) | 66 ± 13 | 65 ± 10 | 0.45 |
| Gender (male/female) | 16/8 | 16/8 | 1.00 |
| WBC (/μL) | 7266 | 6299 | 0.13 |
| TLC (/μL) | 1451 ± 640 | 1803 ± 502 | 0.07 |
| Alb (mg/dL) | 3.8 ± 0.5 | 3.9 ± 0.5 | 0.58 |
| CRP (mg/dL) | 1.23 ± 2.47 | 0.07 ± 0.02 | < 0.05 |
| Tumor characteristic | |||
| Differentiation (tub1/tub2/other) | 13/7/4 | 16/4/4 | 0.53 |
| CEA (</≥ 5 ng/mL) | 16/8 | 18/6 | 1.00 |
| CA19-9 (</≥ 37 IU/mL) | 20/4 | 20/4 | 0.09 |
| Pre-CRT stage (I/II/III) | 1/3/16 | 2/8/12 | 0.17 |
| Treatment | |||
| Chemotherapy (S-1/UFT/5FU) | 13/7/4 | 16/4/4 | 0.57 |
| Surgery (LAR/ISR/APR/local) | 7/4/13/0 | 11/6/5/2 | 0.07 |
| Pathological response (grade 2/> 2) | 17/7 | 15/9 | 0.53 |
Patients were stratified using the median LCR. WBC white blood cell, TLC total lymphocyte count, Alb albumin, CRP C-reactive protein, CEA carcinoembryonic antigen, LCR lymphocyte-CRP ratio, tub1 well-differentiated tubular adenocarcinoma, tub2 moderately differentiated tubular adenocarcinoma, S-1 tegafur-gimeracil-oteracil, UFT tegafur-uracil, 5-FU 5-fluorouracil, CRT chemo-radiotherapy, LAR low anterior resection, ISR intersphincteric resection, APR abdominoperineal resection