Table 4.
Univariate and multivariate analysis of associations between clinicopathological characteristics and overall survival
| Characteristic | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| 5-year OS (%) | P value | Hazard ratio | P value | |
| Age (</≥ 70 years) | 70.1/82.0 | 0.20 | 0.99 | 0.99 |
| Gender (male/female) | 80.4/72.7 | 0.56 | 1.22 | 0.81 |
| WBC (</≥ 9000/μL) | 74.8/100 | 0.31 | 5.13 | 0.39 |
| TLC (</≥ 1500/μL) | 72.2/81.8 | 0.44 | 0.72 | 0.83 |
| Alb (</≥ 4 mg/dL) | 71.5/84.6 | 0.90 | 0.67 | 0.68 |
| CRP (</≥ 0.5 mg/dL) | 77.3/80.0 | 0.77 | 0.10 | 0.14 |
| Tumor characteristic | ||||
| Differentiation (tub1/tub2) | 84.2/70.2 | 0.09 | 3.72 | 0.31 |
| CEA (</≥ 5 ng/mL) | 74.9/84.6 | 0.68 | 0.63 | 0.64 |
| CA19-9 (</≥ 37 IU/mL) | 84.0/42.9 | 0.07 | 19.8 | < 0.05 |
| Pathological response (grade 2/> 2) | 73.2/87.5 | 0.07 | 0.27 | 0.27 |
| fStage (I/II/II) | 86.4/61.9 | < 0.05 | 3.27 | 0.30 |
| Immune factors | ||||
| Pre-CRT PNI (low/high) | 78.2/78.0 | 0.99 | 0.72 | 0.85 |
| Post-CRT PNI (low/high) | 67.1/90.1 | 0.19 | 4.24 | 0.29 |
| Pre-CRT NLR (low/high) | 83.3/73.2 | 0.38 | 0.80 | 0.85 |
| Post-CRT NLR (low/high) | 95.6/61.5 | < 0.05 | 1.15 | 0.92 |
| Pre-CRT LCR (low/high) | 70.3/80.1 | 0.14 | 0.30 | 0.34 |
| Post-CRT LCR (low/high) | 65.5/90.6 | < 0.05 | 0.06 | < 0.05 |
For low/high categories, patients were stratified using the median LCR. WBC white blood cell, TLC total lymphocyte count, Alb albumin, CRP C-reactive protein, CEA carcinoembryonic antigen, tub1 well-differentiated tubular adenocarcinoma, tub2 moderately differentiated tubular adenocarcinoma, S-1 tegafur-gimeracil-oteracil, UFT tegafur-uracil, 5-FU 5-fluorouracil, CRT chemo-radiotherapy, LAR low anterior resection, ISR intersphincteric resection, APR abdominoperineal resection, TLC total lymphocyte count, LCR lymphocyte-CRP ratio, NLR neutrophil-lymphocyte ratio, PNI prognostic nutritional index