. 2021 Jul 7;12:386. doi: 10.1186/s13287-021-02464-w

Table 2.

Showing the role of HSCT and BMT in AIH

	Patient main disorder	Patient gender	Donor	Transplanted cells	Results	Ref.
HSCT	patient with SCD and AIH	Female	Patient’s HbSA haploidentical father	HSCT	- After HSCT by 2 years, the data showed a full donor hematopoiesis, no SCD manifestation was noted, cerebral vasculopathy appeared to be resolved and the patient required no additional medical treatment. Antinuclear and anti-smooth muscle autoantibodies were negative 2 months after HSCT, and there was no recurrence of AIH in the patient.	[89]
BMT	Patient with a 4-year history of AIH and developed acute AL-L2.	Male	His healthy 25-year-old sibling was chosen as an MLC-non-reactive BM donor who was HLA A-, HLA B-, and DR-matched	- 6·8 × 10⁸ bone marrow cells for each kilogram (overall 4·7 × 10¹⁰ cells) - 10⁵ T lymphocytes for each kilogram body from a donor's peripheral blood (overall of 69 × 10⁵ T lymphocytes)	- Allogeneic transplantation of BM and donor T cells resulted in the normalization of T-cell responses to ASGPR, the elimination of antibodies to the same autoantigen, and the noticeable treatment of AIH.	[90]

Patient main disorder

Patient gender

Donor

Transplanted cells

Results

Ref.

HSCT

patient with SCD and AIH

Female

Patient’s HbSA haploidentical father

HSCT

- After HSCT by 2 years, the data showed a full donor hematopoiesis, no SCD manifestation was noted, cerebral vasculopathy appeared to be resolved and the patient required no additional medical treatment. Antinuclear and anti-smooth muscle autoantibodies were negative 2 months after HSCT, and there was no recurrence of AIH in the patient.

[89]

BMT

Patient with a 4-year history of AIH and developed acute AL-L2.

Male

His healthy 25-year-old sibling was chosen as an MLC-non-reactive BM donor who was HLA A-, HLA B-, and DR-matched

- 6·8 × 10⁸ bone marrow cells for each kilogram (overall 4·7 × 10¹⁰ cells)

- 10⁵ T lymphocytes for each kilogram body from a donor's peripheral blood (overall of 69 × 10⁵ T lymphocytes)

- Allogeneic transplantation of BM and donor T cells resulted in the normalization of T-cell responses to ASGPR, the elimination of antibodies to the same autoantigen, and the noticeable treatment of AIH.

[90]

AIH autoimmune hepatitis, SCD sickle cell disease, TCRαβ T cell receptor, PBSC peripheral blood stem cell, HSCT hematopoietic stem cell transplantation, GvHD graft-versus-host disease, AL-L2 acute lymphoblastic leukemia, HLA human leukocyte antigen, MLC mixed leukocytes culture, BMT bone marrow transplantation, ASGPR antiasialoglycoprotein receptor