Figure 2: Diagram of Two-Step procedure (TS).
In the first step, we select sets of biomarkers that are potentially associated with the both the exposure and outcome. In the second step, we test individual biomarkers to identify mediators.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.