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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Hypertension. 2020 Jun 15;76(3):808–818. doi: 10.1161/HYPERTENSIONAHA.120.14833

Table 3 –

Association of categories based on time-averaged cumulative SBP with incident of HF post-V5.

Time-average cumulative measured SBP
 Time-averaged cumulative underlying SBP
Adjusted for demographic Adjusted for demographic + co-morbidities Adjusted for demographic Adjusted for demographic + co-morbidities
BP categories N Event Event rate per 100-person years [95%CI] HR [95%CI] P-value HR [95%CI] P-value N Event Event rate per 100-person years [95%CI] HR [95%CI] P-value HR [95%CI] P-value
HF
Always SBP
<130mmHg		 Without BP meds 647 10 0.28 [0.15-0.53] - - - - 647 10 0.28 [0.15-0.53] - - - -
With BP meds 884 42 0.89 [0.66-1.20] 2.66 [1.33-5.33] 0.006 2.14 [1.02-4.49] 0.044 286 18 1.18 [0.74-1.87] 3.83 [1.77-8.32] 0.001 2.97 [1.29-6.83] 0.01
Either of SBP ≧130mmHg Low cum SBP 1016 59 1.09 [0.85-1.41] 3.37 [1.72-6.60] < 0.001 2.96 [1.46-6.03] 0.003 1215 52 0.79 [0.60-1.04] 2.52 [1.28-4.96] 0.008 2.27 [1.11-4.66] 0.025
Borderline cum SBP 1016 47 0.88 [0.66-1.17] 2.47 [1.24-4.92] 0.01 2.24 [1.09-4.62] 0.029 1215 59 0.92 [0.72-1.19] 2.61 [1.33-5.14] 0.005 2.33 [1.14-4.75] 0.021
High cum SBP 1015 85 1.64 [1.32-2.03] 4.29 [2.20-8.36] < 0.001 3.58 [1.76-7.26] < 0.001 1215 104 1.67 [1.38-2.03] 4.50 [2.32-8.72] < 0.001 3.76 [1.86-7.59] < 0.001
Death
Always SBP <130mmHg Without BP meds 647 59 1.67 [1.30-2.16] - - - - 647 59 1.67 [1.30-2.16] - - - -
With BP meds 884 77 1.60 [1.28-2.00] 0.95 [0.68-1.35] 0.8 0.82 [0.57-1.18] 0.3 286 24 2.54 [2.03-2.30] 0.94 [0.58-1.51] 0.794 0.81 [0.50-1.32] 0.4
Either of SBP ≧130mmHg Low cum SBP 1016 109 1.98 [1.64-2.39] 1.13 [0.82-1.55] 0.5 0.98 [0.70-1.34] 0.9 1215 109 1.64 [1.36 [1.98] 0.95 [0.69-1.30] 0.73 0.89 [0.64-1.24] 0.509
Borderline cum SBP 1016 128 2.35 [1.98-2.80] 1.21 [0.88-1.65] 0.2 1.01 [0.73-1.40] 0.9 1215 148 2.28 [1.94-2.68] 1.23 [0.90-1.67] 0.198 1.00 [0.72-1.38] 0.998
High cum SBP 1015 161 3.02 [2.59-3.53] 1.45 [1.06-1.98] 0.019 1.21 [0.87-1.67] 0.3 1215 194 3.03 [2.64-3.49] 1.52 [1.12-2.06] 0.007 1.23 [0.89-1.69] 0.212
*

Demographic adjustment includes age, sex, race, V5 BMI, and visit center.

Co-morbidity adjustment includes smoking status, DM, CKD, obesity, CHD, and Afib.