TABLE 6.
NOTCH receptors SNPs genotype and allele frequencies in colorectal cancer cases and control population based on gender.
| SNP ID | Genotype | Controls n (frequency) | CRC n (frequency) | Or (95%CI) | χ2 -value | p-value* |
|---|---|---|---|---|---|---|
| Male | ||||||
| rs3124591, NOTCH1 | CC | 45 (0.9) | 39 (0.76) | Ref | ||
| CT | 05 (0.1) | 12 (0.24) | 2.769 (0.896–8.555) | 3.30 | 0.06922 | |
| TT | 00 (00) | 0 (0) | 1.152 (0.022–59.409) | na | 1.00000 | |
| Allele | ||||||
| C | 95 (0.95) | 90 (0.88) | Ref | |||
| T | 05 (0.05) | 12 (0.12) | 2.533 (0.858–7.478) | 3.00 | 0.08337 | |
| rs11249433, NOTCH2 | GG | 08 (0.11) | 11 (0.13) | Ref | ||
| GA | 35 (0.48) | 41 (0.49) | 0.852 (0.308–2.354) | 0.10 | 0.75718 | |
| AA | 30 (0.41) | 31 (0.37) | 0.752 (0.266–2.126) | 0.29 | 0.58971 | |
| Allele | ||||||
| G | 51 (0.35) | 63 (0.38) | Ref | |||
| A | 95 (0.65) | 103 (0.62) | 0.878 (0.553–1.394) | 0.31 | 0.58040 | |
| rs1043994, NOTCH3 | GG | 49 (0.67) | 40 (0.51) | Ref | ||
| GA | 23 (0.32) | 37 (0.47) | 1.971 (1.011–3.841) | 4.01 | 0.04514 | |
| AA | 01 (0.01) | 1 (0.01) | 1.225 (0.074–20.207) | 0.02 | 0.88698 | |
| Allele | ||||||
| G | 121 (0.83) | 117 (0.75) | Ref | |||
| A | 25 (0.17) | 39 (0.25) | 1.613 (0.919–2.832) | 2.80 | 0.09417 | |
| rs3830041, NOTCH4 | CC | 39 (0.53) | 45 (0.54) | Ref | ||
| CT | 28 (0.38) | 34 (0.41) | 1.052 (0.545–2.034) | 0.02 | 0.87927 | |
| TT | 6 (0.08) | 4 (0.05) | 0.578 (0.152–2.197) | 0.66 | 0.41672 | |
| Allele | ||||||
| C | 106 (0.73) | 124 (0.75) | Ref | |||
| T | 40 (0.27) | 42 (0.25) | 0.898 (0.542–1.487) | 0.18 | 0.67470 | |
| Female | ||||||
| rs3124591, NOTCH1 | CC | 37 (0.7) | 35 (0.78) | Ref | ||
| CT | 16 (0.3) | 10 (0.22) | 0.661 (0.265–1.650) | 0.79 | 0.37338 | |
| TT | 0 (0) | 0 (0) | 1.056 (0.020–54.681) | na | 1.00000 | |
| Allele | ||||||
| C | 90 (0.85) | 80 (0.89) | Ref | |||
| T | 16 (0.15) | 10 (0.11) | 0.703 (0.302–1.638) | 0.67 | 0.41263 | |
| rs11249433, NOTCH2 | GG | 5 (0.08) | 5 (0.09) | Ref | ||
| GA | 35 (0.53) | 31 (0.53) | 0.886 (0.234–3.351) | 0.03 | 0.85806 | |
| AA | 26 (0.39) | 22 (0.38) | 0.846 (0.216–3.308) | 0.06 | 0.81009 | |
| Allele | ||||||
| G | 45 (0.34) | 41 (0.35) | Ref | |||
| A | 87 (0.66) | 75 (0.65) | 0.946 (0.560–1.598) | 0.04 | 0.83600 | |
| rs1043994, NOTCH3 | GG | 35 (0.53) | 36 (0.64) | Ref | ||
| GA | 29 (0.44) | 19 (0.34) | 0.637 (0.303–1.338) | 1.42 | 0.23260 | |
| AA | 2 (0.03) | 1 (0.02) | 0.486 (0.042–5.606) | 0.35 | 0.55558 | |
| Allele | ||||||
| G | 99 (0.75) | 91 (0.81) | Ref | |||
| A | 33 (0.25) | 21 (0.19) | 0.692 (0.374–1.283) | 1.37 | 0.24123 | |
| rs3830041, NOTCH4 | CC | 30 (0.45) | 30 (0.52) | Ref | ||
| CT | 26 (0.39) | 16 (0.28) | 0.615 (0.276–1.373) | 1.41 | 0.23437 | |
| TT | 10 (0.15) | 12 (0.21) | 1.200 (0.450–3.197) | 0.13 | 0.71522 | |
| Allele | ||||||
| C | 86 (0.65) | 76 (0.66) | Ref | |||
| T | 46 (0.35) | 40 (0.34) | 0.984 (0.583–1.662) | 0.00 | 0.95185 | |
CRC, colorectal cancer; OR 95% CI, odds ratio and 95% Confidence Interval; na, not analyzable.
* p ≤ 0.05 was considered significant and are depicted in bold.