TABLE 2.
Parameters influencing the DFS.
| Parameters | N (%) | HR | p univariate | p multivariate |
|---|---|---|---|---|
| Age (years), mean (range) | 50.3 (27–77) | |||
| <39 | 11 (13) | 0.26 | 0.146 | |
| ≥39 | 71 (87) | |||
| Side | ||||
| Left | 31 (38) | 3.49 | 0.268 | |
| Right | 50 (62) | |||
| cSt | ||||
| IIa-b | 55 (67) | 0.46 | 0.323 | |
| IIIa-c | 27 (33) | |||
| cT | ||||
| 1–2 | 64 (78) | 0.54 | 0.477 | |
| 3–4 | 18 (22) | |||
| cN | ||||
| 0 | 13 (16) | 0.28 | 0.189 | |
| 1–3 | 69 (84) | |||
| Size (mm), mean (range) | 33.1 (10–60) | |||
| <45 | 65 (79) | 0.21 | 0.068 | 0.208 |
| ≥45 | 17 (21) | |||
| Multifocal/multicentric | ||||
| No | 43 (52) | 1.81 | 0.47 | |
| Yes | 39 (48) | |||
| Location | ||||
| Central | 14 (17) | 1.54 | 0.732 | |
| Non-central | 68 (83) | |||
| ER (%), mean (range) | 25.7 (0–100) | |||
| 0 | 50 (61) | 1.39 | 0.664 | |
| ≥1 | 32 (39) | |||
| PR (%), mean (range) | 9.96 (0–100) | |||
| 0 | 62 (76) | 0.87 | 0.864 | |
| ≥1 | 20 (24) | |||
| HR | ||||
| − | 47 (57) | 1.61 | 0.528 | |
| + | 35 (43) | |||
| Her2 | ||||
| +++ | 67 (82) | 0.98 | 0.986 | |
| ++/FISH+ | 15 (18) | |||
| Ki67 (%), mean (range) | 39.5 (0–80) | |||
| <40 | 44 (54) | 0.52 | ||
| ≥40 | 38 (46) | |||
| Grade | ||||
| 2 | 29 (35) | 3.56 | 0.123 | |
| 3 | 53 (65) | |||
| Histology | ||||
| Ductal | 80 (98) | 2.84 | 0.652 | |
| Other | 2 (2) | |||
| Planned surgery | ||||
| Mastectomy | 79 (96) | 2.83 | 0.778 | |
| Conservative | 3 (4) | |||
| Neoadjuvant cycles | ||||
| <7 | 43 (52) | 0.35 | 0.196 | |
| ≥7 | 39 (48) | |||
| Neoadjuvant + adjuvant cycles | ||||
| <7 | 39 (48) | 0.48 | 0.443 | |
| ≥7 | 43 (52) | |||
| Anthracyclin | ||||
| No | 4 (5) | 0.29 | 0.325 | |
| Yes | 78 (95) | |||
| 5FU | ||||
| no | 33 (40) | 1.59 | 0.564 | |
| yes | 49 (60) | |||
| Surgery | ||||
| Mastectomy | 63 (77) | 0.63 | 0.621 | |
| Conservative | 19 (33) | |||
| Axillary dissection | ||||
| Yes | 67 (82) | 3.62 | 0.17 | |
| No | 15 (18) | |||
| ypT | ||||
| 0–1 | 71 (87) | 0.001 | 1.4 × 10−4 | — |
| 2–4 | 11 (13) | |||
| ypN | ||||
| 0 | 61(74) | 0.03 | 5 × 10−4 | — |
| 1–2 | 21 (26) | |||
| ypSt | ||||
| 0-Ib | 60 (73) | 0.02 | 1.2 × 10−4 | 0.156 |
| IIa-IIIb | 22 (27) | |||
| pCR | ||||
| Yes | 38 (46) | 0.12 | 0.015 | — |
| No | 44 (54) | |||
| Adjuvant chemotherapy | ||||
| Yes | 4 (5) | 0.29 | 0.325 | |
| No | 78 (95) | |||
| WBC (G/l), mean (range) | 7.95 (3.5–18.3) | |||
| <8.04 | 40 (56) | 5.81 | 0.052 | — |
| ≥8.04 | 32 (44) | |||
| NA | 10 | |||
| Neutrophil (G/l), mean (range) | 5.22 (1.44–13.1) | |||
| <4.61 | 35 (49) | 6.54 | 0.037 | |
| ≥4.61 | 36 (51) | |||
| NA | 11 | |||
| Lymphocyte (G/l), mean (range) | 2.05 (0.9–4.01) | |||
| <1.62 | 13 (20) | 5.3 | 0.169 | |
| ≥1.62 | 52 (80) | |||
| NA | 17 | |||
| Monocyte (G/l), mean (range) | 0.51 (0.16–2.58) | |||
| <0.59 | 49 (75) | 0.28 | 0.205 | |
| ≥0.59 | 16 (25) | |||
| NA | 17 | |||
| NLR, mean (range) | 2.68 (0.86–8.39) | |||
| <1.983 | 16 (25) | 14.6 | 0.02 | 0.472 |
| ≥1.983 | 49 (75) | |||
| NA | 17 | |||