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. 2021 Apr 14;27:629829. doi: 10.3389/pore.2021.629829

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Copyright © 2021 Zhou, Zhang, Sun, Lou and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hyperoside alleviates HG-induced apoptosis and inflammation by upregulation of miR-499a-5p. (A) RT-qPCR was performed on extracts of HK-2 cells under different treatments: control; HG; HG + hyperoside to detect miR-499a-5p expression. (B) Knockdown efficiency of miR-499a-5p in HG-treated HK-2 cells was evaluated by RT-qPCR. (C,D) TUNEL and FITC/PI staining assays were applied to detect influence of miR-499a-5p inhibitor on hyperoside in HG-treated HK-2 cells. (E) Western blotting revealed Bcl-2 and Bax proteins. (F,G) Western blotting and ELISA were performed to reveal IL-10, IL-6 and IL-1β levels. **p < 0.01, ***p < 0.001, ns indicates no significance.