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. 2021 Mar 30;27:596899. doi: 10.3389/pore.2021.596899

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Copyright © 2021 Wang, Li, Zhao, Jiang, Song, Qi, Chen, Ju, Hu, Wei, He and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of genes related to DNA repair in ESCA. (A) Enrichment plots showing differential expression of DNA-repair-related genes in normal tissues (n = 11) and tumor tissues (n = 159) according to GSEA. (B) Protein–protein interaction network (n = 102). (C) Functional enrichment (GO and KEGG) analyses of DNA repair genes (n = 102). (D) Interaction of five genes by GeneMANIA. (E) Biological function analysis of the individual five genes in ESCA. Abbreviation: ESCA, esophageal carcinoma; GSEA, gene set enrichment analysis; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.