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. 2021 Mar 5;27:581395. doi: 10.3389/pore.2021.581395

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Copyright © 2021 Kiss, Jámbor, Koroknai, Szász, Bárdos, Mokánszki, Ádány and Balázs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STRING analysis of proteins in WM278 and WM1617 cells. STRING database version 11.0 (http://string-db.org) was used to determine the protein-protein interactions of the 38 proteins differentially expressed in the original and transfected cells. Interactions predicted with high confidence level: 0.700 were included in the analyses, and proteins with no predicted interactions were removed. STRING: Search Tool for the Retrieval of Interacting Genes; AFP: alpha-fetoprotein; ANGPT1: angiopoietin-1; BIRC5: survivin; CA9: carbonic anhydrase IX; CCL2: C-C motif chemokine two; CDH5: VE-cadherin; CDKN1B: cyclin-dependent kinase inhibitor 1B/p27; CTSB: cathepsin B; CTSD: cathepsin D; CTSS: cathepsin S; CXCL8: interleukin-8; EGFR: epidermal growth factor receptor; ENG: endoglin; ERBB2: receptor tyrosine-protein kinase erbB-2; ERBB3: receptor tyrosine-protein kinase erbB-3; FGF2: basic fibroblast growth factor; FOX01: forkhead box protein O1; GRN: progranulin; HMOX1: heme oxygenase one; ICAM1: intercellular adhesion molecule one; IL-6: interleukin-6; LGALS3: galectin-3; MMP3: matrix metallo-proteinase-3; PDGFA: platelet-derived growth factor AA; SNAI1: snail; SPARC: secreted protein acidic and rich in cysteine; SPP1: osteopontin; TNC: tenascin C; TP53: cellular tumor antigen p53; VIM: vimentin; MAPK pathway: The Mitogen-Activated Protein Kinase Pathway; PI3K-Akt pathway: phosphatidylinositol 3-kinase protein kinase B signaling pathway.