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. 2021 Mar 26;27:636088. doi: 10.3389/pore.2021.636088

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Copyright © 2021 Stockhammer, Okumus, Hegedus, Rittler, Ploenes, Herold, Kalbourtzis, Bankfalvi, Sucker, Kimmig, Aigner and Hegedus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PF338 tumor cells are sensitive to both cisplatin and paclitaxel (A) Cisplatin reduced the mesenchymal-like cell fraction of PF338 cells (B) Cells were sensitive to cisplatin (IC₅₀: 0.96 µM) and paclitaxel (IC₅₀: 3.81 nM) (C) Cisplatin induced G2/M arrest and paclitaxel apoptosis (D) Tumor cells could still form colonies when treated with IC₅₀ concentrations of cisplatin. Error bars = means ± SE from three repeats. C/D, control, *p < 0.05, **p < 0.01.