Table 4.
Prevalence of Autoimmune Diseases Within Depression Cases Compared With Depression Controls, Stratified by Possible/Probable for Autoimmune Diseases and Any/Stringent for Depression Cases
| Autoimmune Trait | Autoimmune Prevalence in Depression |
|||||
|---|---|---|---|---|---|---|
| Possible Autoimmune Prevalence |
Probable Autoimmune Prevalence |
|||||
| Any Depression | Stringent Depression | Depression Controls | Any Depression | Stringent Depression | Depression Controls | |
| Any Autoimmune Disease | 10.48% (6 × 10−177) | 14.27% (3 × 10−207) | 6.94% | 6.59% (2 × 10−124) | 9.48% (6 × 10−163) | 4.19% |
| Circulatory System | ||||||
| Pernicious anemia | 0.77% (4 × 10−36) | 1.17% (1 × 10−39) | 0.36% | 0.19% (4 × 10−8) | 0.35% (4 × 10−15) | 0.10% |
| Endocrine System | ||||||
| Autoimmune thyroid disease | 0.41% (6 × 10−19) | 0.58% (1 × 10−16) | 0.20% | 0.28% (6 × 10−13) | 0.39% (3 × 10−11) | 0.14% |
| Type 1 diabetes | 1.20% (3 × 10−31) | 2.07% (5 × 10−59) | 0.69% | 1.02% (1 × 10−27) | 1.65% (5 × 10−43) | 0.58% |
| Nervous System | ||||||
| Multiple sclerosis | 0.87% (6 × 10−56) | 1.31% (5 × 10−54) | 0.35% | 0.63% (3 × 10−51) | 1.02% (8 × 10−57) | 0.22% |
| Myasthenia gravis | 0.11% (5 × 10−5) | 0.17% (5 × 10−6) | 0.05% | 0.06% (3 × 10−2) | 0.12% (4 × 10−5) | 0.04% |
| Digestive System | ||||||
| Celiac | 0.92% (3 × 10−12) | 1.08% (4 × 10−8) | 0.64% | 0.54% (2 × 10−12) | 0.64% (7 × 10−8) | 0.33% |
| Inflammatory bowel disease | 1.82% (6 × 10−11) | 2.56% (8 × 10−22) | 1.43% | 1.28% (3 × 10−8) | 1.85% (2 × 10−17) | 1.00% |
| Skin | ||||||
| Psoriasis | 2.05% (2 × 10−22) | 2.55% (4 × 10−20) | 1.46% | 1.10% (1 × 10−17) | 1.47% (4 × 10−18) | 0.73% |
| Musculoskeletal System and Connective Tissue | ||||||
| Ankylosing spondylitis | 0.52% (5 × 10−7) | 0.72% (7 × 10−9) | 0.37% | 0.17% (5 × 10−4) | 0.25% (9 × 10−5) | 0.11% |
| Polymyalgia rheumatica/GCA | 0.66% (2 × 10−13) | 0.93% (3 × 10−15) | 0.42% | 0.35% (5 × 10−6) | 0.51% (1 × 10−8) | 0.23% |
| Psoriatic arthritis | 0.50% (3 × 10−15) | 0.58% (1 × 10−8) | 0.28% | 0.38% (5 × 10−16) | 0.51% (2 × 10−13) | 0.19% |
| Rheumatoid arthritis | 2.66% (5 × 10−62) | 4.14% (3 × 10−92) | 1.59% | 1.42% (6 × 10−28) | 2.23% (1 × 10−45) | 0.89% |
| Sjögren syndrome | 0.34% (4 × 10−25) | 0.55% (2 × 10−28) | 0.13% | 0.21% (1 × 10−17) | 0.33% (7 × 10−18) | 0.08% |
| Systemic lupus erythematosus | 0.36% (2 × 10−25) | 0.59% (6 × 10−30) | 0.14% | 0.23% (2 × 10−22) | 0.39% (8 × 10−27) | 0.08% |
The p values from pairwise comparisons of autoimmune prevalence in depression cases compared with depression controls are shown in parentheses.