Table 1.

Fluconazole and ATI-2307 IC₅₀, and amphotericin B IC₉₀ values, for high IC₅₀ fluconazole Cryptococcal neoformans clinical isolates*.

IC₅₀ and IC₉₀ values were determined using the EUCAST microbroth dilution method (Arendrup et al., 2017).

*A total of 69 isolates were screened, and data are presented as the number (cumulative percentage) of isolates with growth inhibition at (or below, for cumulative percentage) the indicated drug concentration.

^†Low IC₅₀/IC₉₀ ranges are indicated in the dashed box. Fluconazole IC₅₀ values < 8 μg/mL are considered low. IC₉₀ values ≤1 µg/mL are considered low for amphotericin B. IC₅₀ values ≤0.0624 µg/mL are susceptible to ATI-2307 based on murine studies (Mitsuyama et al., 2008).