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. 2021 Jun 8;6(11):e139160. doi: 10.1172/jci.insight.139160

Figure 3. Silencing ADRB3 in human brown/beige adipocytes lowers lipolysis-activated UCP1-induced uncoupled and maximal respiration.

Figure 3

(A and B) OCR (A) and quantification of respiratory profile by differentiated siRNA-Ctrl and siRNA-ADRB3 transfected adipocytes (B). (C–G) OCR trace (C), quantification of respiratory profile (D), Fsk-induced proton leak (E), and Fsk-induced maximal respiration (F) and spare respiratory capacity (G) in the presence of 2% BSA by differentiated siRNA-Ctrl– and siRNA-ADRB3–transfected adipocytes. Two-tailed unpaired Student’s t test was used for statistical analysis. ****P < 0.0001.