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. 2021 May 10;6(9):e145523. doi: 10.1172/jci.insight.145523

Figure 5. BNZ-PSs are significantly less toxic than free BNZ.

Figure 5

Healthy mice (n = 5 per group) were treated with BNZ (100 mg/kg) or BNZ-PS (1.5 or 0.15 mg/kg), plus controls. (A) Mice treated with BNZ, but not BNZ-PS, lost weight during 2 weeks of treatment. Weights were determined every few days. *P ≤ 0.05 vs. untreated. (B) Mice treated with BNZ show hepatotoxicity as reflected by increased serum ALT on day 21. Serum ALT was also measured and did not show significant elevation in any mouse. *P ≤ 0.0001. All error bars reflect mean ± SEM. One-way ANOVA with Tukey’s post hoc test was used for multiple comparisons. ALT, alanine aminotransferase.