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. 2021 May 10;6(9):e138484. doi: 10.1172/jci.insight.138484

Figure 4. Treatment with nanoparticle-encapsulated FL2-siRNA improves recovery of erectile response following CN injury.

Figure 4

(A) Schematic of cavernosometry setup. Cannulas are inserted into the penile cruz and the carotid artery to measure the ICP and BP, respectively. A bipolar stainless steel electrode, inserted above the site of nerve injury, is used to directly stimulate the CN. (B) Traces of the ICP in response to increasing levels of CN stimulation in an uninjured animal and an animal following cavernous nerve injury. (C) Time course showing the ratio of ICP to mean BP (ICP/BP) of control-npsi– and FL2-npsi– treated nerves with 1 mA electrostimulation of the nerve (5–6 animals per time point and treatment group — note the experiment is terminal and a different cohort was used for each time point). (D) ICP/BP for naive and npsi-treated rats 4 weeks after crush and treatment (Control Npsi n = 6; FL2 Npsi n = 5; naive n = 5). Data are presented as mean ± SEM and were analyzed using unpaired 2-tailed Student’s t test (C) or 1-way ANOVA with Tukey’s test (D). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.