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. 2021 May 10;6(9):e134340. doi: 10.1172/jci.insight.134340

Figure 1. Lipin 1 is deactivated in failing human heart.

Figure 1

(A) The schematic depicts the sequential acylation of glycerol-3-phosphate (G3P) to generate triglyceride. LPA, lysophosphatidic acid; PA, phosphatidic acid; DAG, diacylglycerol; CDP, cytosine diphosphate; PI, phosphatidylinositol; PG, phosphatidylglycerol; CL, cardiolipin; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phosphatidylserine. (B and C) Lipin 1 protein abundance (B) and mRNA expression (C) is significantly diminished in cardiac tissue of people with heart failure. Densitometry for the sum of both lipin 1 bands (normalized arbitrary units) is inset between the blots. Data represent mean ± SEM. *P < 0.05 by t test (n = 15 and 9/group).