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. 2021 May 10;6(9):e134340. doi: 10.1172/jci.insight.134340

Figure 2. cs-Lpin1–/– mice are viable and exhibit minimal cardiac phenotype at baseline.

Figure 2

(A and B) Lipin 1 mRNA expression (A) and protein abundance (B) is significantly diminished in the hearts of cs-Lpin1–/– mice. (C) No difference was observed in biventricular weight between cs-Lpin1–/– mice and littermate controls. (D) cs-Lpin1–/– mice had increased expression of fetal program genes (Nppa, Nppb, Myh7, and Acta1). (E) Histologic findings were normal in the hearts of 10-week-old cs-Lpin1–/– mice. Scale bars: 1000 μm. (F) No differences in gene markers of autophagy or inflammation are seen in the hearts of cs-Lpin1–/– mice. (G) Electron micrographs reveal no differences in mitochondrial ultrastructure in the hearts of cs-Lpin1–/– mice. Scale bars: 200 nm. Data represent mean ± SEM. *P < 0.05 by ANOVA (n = 4–9/group).