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. 2021 May 24;6(10):e146728. doi: 10.1172/jci.insight.146728

Figure 1. Deletion of Sirt3 prevents age-associated cortical bone loss.

Figure 1

(A–D) Imaging and quantification of femoral bones from female Sirt3-KO mice and WT littermates by micro-CT after sacrifice (n = 7–10 animals/group). (A) Representative images of femoral cortical bone at midshaft. Scale bar: 100 μm. (B–D) Cortical thickness (B) and cortical perimeters (C and D) at the femoral midshaft. (E) Cortical thickness at the femoral midshaft of the femur from male Sirt3-KO mice and WT littermates by micro-CT (n = 5–7 animals/group). Data are presented as ± SD. P values were determined using 2-way ANOVA. Interaction terms generated by 2-way ANOVA are shown below each graph.