Figure 3. Characteristics of the transcriptional landscape differentiating the quiescent (Q) and nonquiescent (NQ) molecular phenotypes.
Enrichment map of gene sets exhibiting significant enrichment by the GSEA algorithm (P < 0.005, FDR < 0.1) based on the transcriptional expression signature in myometrial samples. Markov cluster analysis was used to identify 9 dense subclusters within the network, indicated by the labeled ellipses. Within the network diagram, node size reflects the number of genes in each enriched set, node color indicates the direction of enrichment, and edges represent the overlap coefficient between adjacent nodes as a similarity metric. The blue arrow indicates the KEGG calcium signaling pathway within a subnetwork enriched for Ca2+ binding and Ca2+ transport genes.