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. 2021 May 10;6(9):e145607. doi: 10.1172/jci.insight.145607

Figure 4. Continuous infusion of TMA — a microbial metabolite with low hepatic first-pass metabolism.

Figure 4

(A) Peripheral plasma levels of trimethylamine (TMA) in male C57BL/6 mice receiving TMA via intraportal catheter (n =2–3). Single-housed controls (SH), sham surgery controls (Sham), and osmotic pump normal saline controls (NS) are also shown. (B) Peripheral plasma trimethylamine-N-oxide (TMAO) levels in male C57BL/6 mice. (C) Peripheral plasma levels of TMA in female C57BL/6 mice (n = 2-3). SH, Sham, and NS controls are also shown. (D) Peripheral plasma TMAO levels in female C57BL/6 mice.