Figure 7. Molecular mechanism for the P2Y₁₄R function in white adipocytes.

Activation of Gi-coupled P2Y₁₄R in adipocytes inhibits lipolysis via decreasing cAMP levels resulting in decreased phosphorylation and activity of lipolytic enzymes. Adipocyte-specific KO of P2Y₁₄R causes increase in cAMP levels, increasing phosphorylation and activity of lipolytic enzymes, enhancing lipolysis in fasting conditions. Mice lacking P2Y₁₄R in adipocytes were protected from obesity and associated metabolic deficits on high fat diet. P2Y, purinergic; AC, adenylate cyclase; cAMP, cyclic adenosine monophosphate; HSL, hormone-sensitive lipase; ATGL, adipose triglyceride lipase; TG, triglycerides; FFA, free fatty acid; P, phosphorylation.