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. 2021 May 24;6(10):e143037. doi: 10.1172/jci.insight.143037

Figure 3. ZnT8B–/– hIAPP mice fed a high-fat diet show impaired glucose tolerance and insulin secretion in vivo.

Figure 3

(A) Body weight, (B) 5-hour fasted blood glucose, (C) overnight fasted plasma insulin, (D) OGTT and incremental area under the glucose curve, (E) plasma insulin during OGTT and incremental area under the insulin curve, with (F) glucose-stimulated insulin secretion expressed as fold change over basal. (G) Insulin tolerance test (ITT) with (H) expression as fold change over basal. Data are represented as mean ± SEM. (A–H) Control (n = 23), ZnT8B–/– (n = 16), hIAPP (n = 22), and ZnT8B–/– hIAPP (n = 17). One-way ANOVA with Tukey’s adjustment was used in A–E. Two-way ANOVA with Dunnett’s correction was used in D–H. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, all groups compared with control. #P < 0.05, ##P < 0.01, ####P < 0.0001, all groups compared with ZnT8B–/–. $P < 0.05, $$$P < 0.001, $$$$P < 0.001, all groups compared with hIAPP.