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. 2021 Jun 8;6(11):e147617. doi: 10.1172/jci.insight.147617

Figure 5. scRNA-Seq analysis of 2 PDXs identifies clusters associated with differential drug response.

Figure 5

(A) Combined analysis of tumor cells from n = 2 samples per each PDX and each condition (total 24 samples, average cell number per sample = 2355). UMAP plots colored by cluster (top panel), PDX (middle panel), and treatment (bottom panel). (B) Cell distribution among clusters based on PDX from which they were derived. Red color, lower than expected frequency; blue, higher than expected. P value of χ2 test is shown. (C) Cell distribution in different clusters based on treatment. Red color indicates lower than expected frequency; blue, higher than expected. P value of χ2 test is shown. (D) MetaCore Pathway enrichment analysis for genes enriched in clusters differentially affected by distinct treatments (clusters 0, 3, 4, and 5). Circle size corresponds to number of genes found per pathway.