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. Author manuscript; available in PMC: 2021 Jul 7.
Published in final edited form as: IEEE/ACM Trans Comput Biol Bioinform. 2018 Jul 23;16(4):1143–1153. doi: 10.1109/TCBB.2018.2858794

Fig. 3:

Fig. 3:

(a) Pareto frontier of 15-site point mutation GFP libraries. Selected library plans in sequence-optimized (green), structure-optimized (orange) and sequence-structure-optimized (yellow) regions are enumerated (random 1000 variants in each) and displayed as contours, (b) Amino acid composition of Pareto optimal 15-site point mutation GFP libraries. The seven panels represent different regions of the Pareto frontier, green for sequence-optimized, orange for structure-optimized and yellow for sequence-structure-optimized. The height of sequence logos corresponds to the abundance of mutations in the plans (wild-type not shown). Experimentally observed mutations are highlighted in blue.