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. Author manuscript; available in PMC: 2021 Jul 7.
Published in final edited form as: IEEE/ACM Trans Comput Biol Bioinform. 2018 Jul 23;16(4):1143–1153. doi: 10.1109/TCBB.2018.2858794

Fig. 4:

Fig. 4:

(a) Comparison of sequence homology and structure energy scores of available choices at position 169 that lead to the selection of tyrosine in GFP. Lower scores correspond to more favorable contributions. Comparison of (b) wild-type GFP and (c) structure energy optimized 15-point mutation plan variant illustrating formation of a favorable hydrogen bond with P58 upon H169Y mutation.