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Comparison of sites targeted by sequence-only optimization (green spheres), structure-only optimization (orange spheres) and sequence-structure optimization (yellow spheres) for P450 15-site degenerate oligo library plans. Balanced sequence-structure optimization (elbow plan) sites that overlap with sequence-only and structure-only sites are shown by green and orange circles, respectively. Position 123, targeted by all three plans, is shown by a yellow sphere with a blue circle.
