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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Anal Chem. 2021 Jun 8;93(24):8476–8483. doi: 10.1021/acs.analchem.1c00716

Figure 5.

Figure 5.

Pilot optimization of SABRE-SHEATH hyperpolarization of [1-13C]pyruvate: a) magnetic field sweep of a sample of [Ir(COD)(IMes)] (13 mM) with sodium [1-13C]pyruvate (90 mM) and DMSO (120 mM) in 0.6 mL methanol-d4 at room temperature; b) temperature sweep of a sample of [Ir(COD)(IMes)] (7.8 mM) sodium [1-13C]pyruvate (30 mM) and DMSO (20 mM) in 0.6 mL methanol-d4 at BT=−0.7 μT; c) p-H2 bubbling duration sweep using a sample of [Ir(COD)(IMes)] (7.8 mM) with sodium [1-13C]pyruvate (30 mM) and DMSO (20 mM) in 0.6 mL methanol-d4 at BT=−0.7 μT; d) In-shield 13C T1 signal decay using a sample of [Ir(COD)(IMes)] (7.8 mM) with sodium [1-13C]pyruvate (30 mM) and DMSO (20 mM) in 0.6 mL methanol-d4 at BT=−0.7 μT; e) SABRE catalyst concentration sweep using samples of 30 mM of sodium [1-13C]pyruvate and 20 mM DMSO in 0.6 mL methanol-d4 at BT=−0.7 μT. All experiments were performed using with 100 PSI p-H2 (~50% para-) overpressure at ~100 sccm flow rate.