FIG. 3.

MAO-derived byproducts disrupt oxPHOS. Simultaneous (A) ATP production, (B) O₂ consumption, and (C) ATP/O ratio were measured in permeabilized fibers prepared from atrial myocardium treated with: no MAO substrate or inhibitors, 75 μM NE, MAO inhibitors, or MAO inhibitors +75 μM NE. n = 10/metabolic group with 4 fibers from each patient. (A–C) were analyzed by using one-way ANOVA followed by unpaired t-tests. *p < 0.05 with unpaired t-tests. ND, nondiabetes; OxPHOS, oxidative phosphorylation.