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. 2021 Jun 22;6(12):e147984. doi: 10.1172/jci.insight.147984

Figure 2. SETDB2 is highly expressed in atherosclerotic macrophages.

Figure 2

(A) Representative elastic van Gieson (EvG) staining from healthy (top) and atherosclerotic (bottom) human coronary arteries. (B) Representative immunofluorescence analysis of SETDB2 and CD68 expression in human coronary lesions. (C) qRT-PCR analysis of Setdb2 expression in healthy (no/mild, n = 3) and atherosclerotic arteries (severe plaque, n = 7). Quantification represents the mean ± SEM of relative expression levels normalized to healthy artery. *P < 0.05. Data were analyzed by an unpaired 2-tailed Student’s t test. (D) Representative immunofluorescence analysis of SETDB2 and CD68 expression in mouse atherosclerotic plaques. Dashed bars indicate the atherosclerotic plaques. Scale bar: 100 μm. L, lumen.