Figure 5. Wilcoxon signed-rank statistics of free and bound sodium fractions.

Wilcoxon signed-rank statistics of free and bound sodium fractions determined from 2-dimensional ²³Na TQ-TPPI maps, and of skin sodium binding capacity, defined as bound to free sodium ratio, for control (n = 14 collected from 5 patients) and diabetic (n = 19 collected from 9 patients) skin biopsies. (A) Compared with T2D, control skin samples had greater retention of free sodium release, with P < 0.05, while there is an increase in bound sodium in controls, with P < 0.05. (B) There is augmentation of skin sodium binding capacity for skin samples from controls versus those from patients with T2D, with P < 0.05, as shown in B.