TABLE 2.
Main effects of polygenic scores on blood pressure, within and across cohorts.
| Individual cohort results | β (SE) | t | p | |||
| Systolic blood pressure | ||||||
| CHOICE/DCS/OPT AA | 0.68 (1.36) | 0.50 | 0.62 | |||
| GTP AA | 2.11 (0.73) | 2.91 | 3.8E-3 | |||
| HOST AA | 0.59 (0.61) | 0.97 | 0.34 | |||
| MRS AA | 1.37 (0.83) | 1.66 | 0.10 | |||
| SHRS AA | 1.20 (0.88) | 1.36 | 0.18 | |||
| CHOICE/DCS/OPT EA | 2.31 (1.11) | 2.07 | 0.04 | |||
| GMRF-QUT EA | 2.26 (0.93) | 2.43 | 0.02 | |||
| HOST EA | 0.51 (0.82) | 0.62 | 0.54 | |||
| MRS EA | 1.67 (0.26) | 6.30 | 3.8E-10 | |||
| TRACTS EA | 0.89 (0.65) | 1.37 | 0.17 | |||
| UKBB EA | 3.03 (0.07) | 45.2 | <1E-20 | |||
| VETSA EA | 1.48 (0.46) | 3.20 | 1.4E-3 | |||
|
| ||||||
| Meta-analysis results | β (SE) | z | p | Q | p-het | I 2 |
|
| ||||||
| Trans-ethnic meta-analysis | 2.83 (0.06) | 45.16 | <1E-20 | 78.22 | 3.3E-12 | 85.9 |
| Trans-ethnic meta-analysis without UKBB | 1.46 (0.18) | 8.32 | 8.8E-17 | 7.35 | 0.69 | 0 |
| AA meta-analysis | 1.20 (0.36) | 3.38 | 7.2E-4 | 2.79 | 0.59 | 0 |
| EA meta-analysis without UKBB | 1.54 (0.20) | 7.64 | 2.2E-14 | 3.89 | 0.56 | 0 |
|
| ||||||
| Individual cohort results | β (SE) | t | p | |||
|
| ||||||
| Diastolic blood pressure | ||||||
| CHOICE/DCS/OPT AA | 1.99 (0.94) | 2.12 | 0.04 | |||
| GTP AA | 1.82 (0.42) | 4.28 | 2.1E-5 | |||
| HOST AA | −0.12 (0.51) | −0.24 | 0.81 | |||
| MRS AA | 0.48 (0.63) | 0.77 | 0.44 | |||
| SHRS AA | 1.28 (0.60) | 2.13 | 0.03 | |||
| CHOICE/DCS/OPT EA | 2.13 (0.86) | 2.46 | 0.02 | |||
| GMRF-QUT EA | 0.17 (0.43) | 0.39 | 0.69 | |||
| HOST EA | 0.87 (0.55) | 1.59 | 0.12 | |||
| MRS EA | 0.80 (0.22) | 3.63 | 2.9E-4 | |||
| TRACTS EA | 0.80 (0.53) | 1.52 | 0.13 | |||
| UKBB EA | 1.37 (0.04) | 34.40 | <1E-20 | |||
| VETSA EA | 0.76 (0.26) | 2.94 | 3.3E-3 | |||
|
| ||||||
| Meta-analysis results | β (SE) | z | p | Q | p-het | I 2 |
|
| ||||||
| Trans-ethnic meta-analysis | 1.32 (0.04) | 34.84 | <1E-20 | 33.08 | 5.0E-4 | 66.8 |
| Trans-ethnic meta-analysis without UKBB | 0.83 (0.12) | 6.70 | 2.1E-11 | 15.99 | 0.10 | 37.5 |
| AA meta-analysis | 1.06 (0.25) | 4.20 | 2.7E-5 | 10.40 | 0.03 | 61.6 |
| EA meta-analysis without UKBB | 0.76 (0.14) | 5.33 | 9.8E-8 | 4.51 | 0.48 | 0 |
Models adjusted for the first five ancestry principal components, age, age-squared, and sex (for cohorts with men and women). AA = African ancestry; DCS = D-cycloserine Study; EA = European ancestry; GMRF-QUT = Gallipoli Medical Research Foundation-Queensland University of Technology; GTP = Grady Trauma Project; HOST = Hostility, PTSD, and Physical Health Risk Factors; MRS = Marine Resiliency Study; OPT = Optimizing Treatment for PTSD; p-het = p-value for Cochran’s Q; Q = Cochran’s Q; SE = standard error; SHRS = Shared Roots Study; TRACTS = Translational Research Center for TBI and Stress Disorders; UKBB = UK Biobank; VETSA = Vietnam Era Twin Study of Aging.