TABLE 3.
Main effects of PTSD symptoms on blood pressure, within and across cohorts.
| Individual cohort results | β (SE) | t | p | |||
| Systolic blood pressure | ||||||
| CHOICE/DCS/OPT AA | 14.82 (7.13) | 2.08 | 0.04 | |||
| GTP AA | −2.56 (2.89) | −0.89 | 0.38 | |||
| HOST AA | −2.77 (6.91) | −0.40 | 0.69 | |||
| MRS AA | 6.59 (6.95) | 0.95 | 0.35 | |||
| SHRS AA | 1.23 (3.40) | 0.36 | 0.72 | |||
| CHOICE/DCS/OPT EA | 3.57 (9.14) | 0.39 | 0.70 | |||
| GMRF-QUT EA | −16.32 (14.62) | −1.12 | 0.27 | |||
| HOST EA | 0.48 (7.38) | 0.06 | 0.95 | |||
| MRS EA | 6.22 (2.04) | 3.05 | 2.3E-3 | |||
| TRACTS EA | 2.01 (2.73) | 0.74 | 0.46 | |||
| UKBB EA | −2.24 (0.48) | −4.64 | 3.4E-6 | |||
| VETSA EA | 2.73 (3.09) | 0.88 | 0.38 | |||
|
| ||||||
| Meta-analysis results | β (SE) | z | p | Q | p-het | I 2 |
|
| ||||||
| Trans-ethnic meta-analysis | −1.46 (0.44) | −3.30 | 9.8E-4 | 29.03 | 2.0E-3 | 62.1 |
| Trans-ethnic meta-analysis without UKBB | 2.81 (1.13) | 2.49 | 0.01 | 12.16 | 0.27 | 17.8 |
| AA meta-analysis | 0.63 (1.93) | 0.33 | 0.74 | 6.18 | 0.19 | 35.3 |
| EA meta-analysis without UKBB | 3.94 (1.39) | 2.83 | 4.7E-3 | 4.05 | 0.54 | 0 |
|
| ||||||
| Individual cohort results | β (SE) | t | p-value | |||
|
| ||||||
| Diastolic blood pressure | ||||||
| CHOICE/DCS/OPT AA | 1.37 (5.23) | 0.26 | 0.79 | |||
| GTP AA | −3.72 (1.73) | −2.16 | 0.03 | |||
| HOST AA | 1.17 (4.77) | 0.25 | 0.81 | |||
| MRS AA | 0.47 (5.11) | 0.09 | 0.93 | |||
| SHRS AA | 1.57 (2.30) | 0.68 | 0.50 | |||
| CHOICE/DCS/OPT EA | −3.60 (6.69) | −0.54 | 0.59 | |||
| GMRF-QUT EA | −1.51 (6.97) | −0.22 | 0.83 | |||
| HOST EA | −1.30 (4.05) | −0.32 | 0.75 | |||
| MRS EA | 2.79 (1.69) | 1.65 | 0.10 | |||
| TRACTS EA | 1.69 (2.21) | 0.77 | 0.44 | |||
| UKBB EA | 0.74 (0.28) | 2.62 | 0.01 | |||
| VETSA EA | 1.19 (1.72) | 0.69 | 0.38 | |||
|
| ||||||
| Meta-analysis results | β (SE) | z | p-value | Q | p-het | I 2 |
|
| ||||||
| Trans-ethnic meta-analysis | 0.70 (0.26) | 2.65 | 8.1E-3 | 9.34 | 0.59 | 0 |
| Trans-ethnic meta-analysis without UKBB | 0.43 (0.78) | 0.55 | 0.58 | 9.20 | 0.51 | 0 |
| AA meta-analysis | −1.30 (1.25) | −1.04 | 0.30 | 4.18 | 0.38 | 4.3 |
| EA meta-analysis without UKBB | 1.54 (1.00) | 1.54 | 0.12 | 1.87 | 0.87 | 0 |
Models adjusted for the first five ancestry principal components, age, age-squared, and sex (for cohorts with men and women). AA = African ancestry; DCS = D-cycloserine Study; EA = European ancestry; GMRF-QUT = Gallipoli Medical Research Foundation-Queensland University of Technology; GTP = Grady Trauma Project; HOST = Hostility, PTSD, and Physical Health Risk Factors; MRS = Marine Resiliency Study; OPT = Optimizing Treatment for PTSD; p-het = p-value for Cochran’s Q; PTSD = posttraumatic stress disorder; Q = Cochran’s Q; SE = standard error; SHRS = Shared Roots Study; TRACTS = Translational Research Center for TBI and Stress Disorders; UKBB = United Kingdom Biobank; VETSA = Vietnam Era Twin Study of Aging.