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. 2021 Jun 23;15:697509. doi: 10.3389/fnbeh.2021.697509

FIGURE 3.

FIGURE 3

Incubation of oxycodone craving following adult-onset and adolescent-onset oxycodone self-administration under the group-housing condition. (A,B) Data are mean ± SEM number of oxycodone (0.1 mg/kg/infusion) infusions, total oxycodone intake, and lever presses during the ten 6-h daily self-administration sessions for Exp. 2. During training, active lever presses were reinforced on an FR1 20-s timeout reinforcement schedule, and oxycodone infusions were paired with a 5-s tone-light cue. (C) Relapse test on abstinence days 1 and 15: Data are mean ± SEM of active and inactive lever presses during the 30-min relapse test on abstinence day 1 and the first 30 min of the 60-min relapse test on abstinence day 15. #Main effect of Age; *Different from Adult, p < 0.05. (D) Relapse test on abstinence day 15: Data are mean ± SEM of active and inactive lever presses during the 60-min relapse test. During testing, active lever presses led to contingent presentations of the tone-light cue previously paired with oxycodone infusions during training, but not oxycodone. n = 11–14/group.