Figure 3. Anti-ricin treatment does not alleviate SARS-CoV-2–induced body weight loss of LDR mice.
Two days after i.n. application of LDR (1.7 μg/kg), mice were treated (i.p.) with anti-ricin antibodies (1730 IsNU/mouse; ref. 14) and 2 hours later were infected (black squares) or not (white triangles) with SARS-CoV-2 (5 × 106 PFU/mouse). Body weights of CD-1 mice were monitored over a period of 15 days after viral infection. Data, presented as percentage of original weight determined at the time of virus instillation, are mean ± SEM, n = 4–5 per group, analyzed using 2-way ANOVA followed by Bonferroni’s posttests, ***P < 0.001 compared with no virus. A representative experiment out of 3 independent experiments is displayed.