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. 2021 Apr 15;131(8):e135963. doi: 10.1172/JCI135963

Figure 7. Skeletal muscle lipid composition and contractility in LPCAT3-MKO mice.

Figure 7

(A–C) Lipids were extracted from gastrocnemius muscles of Ctrl and LPCAT3-MKO mice for mass spectrometric analysis. Quantification of lyso-PC (A), PC (B), and total lyso-PC/PC (C) (Ctrl n = 4, MKO n = 7). (D–I) Extensor digitorum longus (EDL) muscles of Ctrl and LPCAT3-MKO mice were dissected for measurement of mass (D), force produced with a pulse stimulation (E and F), force produced with tetanic stimulation ranging from 10 to 200 Hz (G and H) (H, force tracing at 200 Hz stimulation) (Ctrl n = 6, MKO n = 9), and skeletal muscle fiber type (MHC I, pink; MHC IIa, green; MHC IIb, red; MHC IIx, negative) (I). Two-tailed t tests (A–E) or 2-way ANOVA with Šidák’s multiple-comparison test (G) was performed. All data are represented as mean ± SEM. *P ≤ 0.05.