Table 3.

QOL point change at cycle 4 from baseline between Arm A and B

QOL	Arm A		Arm B		p-value
	n	median (range)	n	median (range)
QOL overall	11	0 (−5, 1)	25	−1 (−6, 5)	0.26
Fatigue	11	1 (−3, 7)	25	0 (−4, 8)	0.75
Rash	10	0 (−4, 2)	25	0 (−5, 10)	0.095
Diarrhea	11	2 (−10, 8)	25	1 (−8, 8)	0.99
Hands and feet syndrome (skin or pain change)	11	2 (−1, 8)	25	4 (−7, 10)	0.42

Note: The positive value of QOL overall score represents better QOL after 4 cycles of treatment; the positive value of fatigue, rash, diarrhea, and hands and feet syndrome score represents worse syndrome at cycle 4. N represents sample size.