Table 1:

Pharmacokinetic Properties of elagolix in Healthy Subjects

Absorption
Tmax (h)	1.5(1.0 – 4.0)
Effect of Food
High-fat meal (826kcal, 52% fat, relative to fasting)	AUC: ↓25%, Cmax: ↓36%
Distribution
% Bound to human plasma proteins	80
Blood-to-plasma ratio	0.6
Metabolism	CYP3A (major)Minor pathways include: CYP2D6, CYP2C8, and uridine glucuronosyl transferases (UGTs)
Elimination
Major route of elimination	Hepatic metabolism
Terminal phase elimination half-life (t1/2) (h)	5.9± 2.1
% of dose excreted in urine	<3
% of dose excreted in feces	90