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[ 18 F]81 was synthesized from its corresponding sulfonyl chloride 79 using [18F]fluoride in a cesium carbonate aqueous solution followed by oxidation with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH). [ 18 F]81 reacts with tyrosine under basic (pH 9–10) conditions at room temperature and could be potentially used for the indirect radiolabeling of proteins at this residue.
