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. 2021 Jun 23:NEJMsr2105280. doi: 10.1056/NEJMsr2105280

Table 2. Key Spike Protein Mutations in Five SARS-CoV-2 Variants.

Variant Phenotypic Change Amino Acid Position in Prototype Virus and Proposed Effect of Changing It*
Δ69–70
Increase
transmission
K417
Decrease
neutralization
L452
Decrease
neutralization
E484
Decrease
neutralization
N501
Increase
transmission
D614
Increase
transmission
P681
Increase
transmission
B.1.1.7 (or alpha) Increase transmission 69–70 deleted K (later change) Y G H
B.1.351 (or beta) Increase transmission and virulence N K Y G
B.1.1.28.1 (or gamma or P.1) Increase transmission and virulence, decrease neutralization N/T K Y G
B.1.617.2 (or delta) Increase transmission, decrease neutralization R R R
B.1.617.1 (or kappa) Increase transmission, decrease virulence R Q G R
*

Single letter codes of amino acid changes at specified positions for the listed variants are shown.

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