Table 2. Key Spike Protein Mutations in Five SARS-CoV-2 Variants.
Variant | Phenotypic Change | Amino Acid Position in Prototype Virus and Proposed Effect of Changing It* | ||||||
---|---|---|---|---|---|---|---|---|
Δ69–70 Increase transmission |
K417 Decrease neutralization |
L452 Decrease neutralization |
E484 Decrease neutralization |
N501 Increase transmission |
D614 Increase transmission |
P681 Increase transmission |
||
B.1.1.7 (or alpha) | Increase transmission | 69–70 deleted | K (later change) | Y | G | H | ||
B.1.351 (or beta) | Increase transmission and virulence | N | K | Y | G | |||
B.1.1.28.1 (or gamma or P.1) | Increase transmission and virulence, decrease neutralization | N/T | K | Y | G | |||
B.1.617.2 (or delta) | Increase transmission, decrease neutralization | R | R | R | ||||
B.1.617.1 (or kappa) | Increase transmission, decrease virulence | R | Q | G | R |
Single letter codes of amino acid changes at specified positions for the listed variants are shown.