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. 2021 Jul 5;48(2):164. doi: 10.3892/ijmm.2021.4996

Figure 5.

Figure 5

AS-IV mitigates NLRP3 inflammasome activation in podocytes of the glomeruli of db/db mice. Colocalization of (A) NLRP3 with synaptopodin and (B) caspase-1 with synaptopodin (a podocyte marker) in the glomeruli of WT control mice, and vehicle- and AS-IV-treated mice (scale bar, 20 µm; magnification, ×200). Mean fluorescence intensity of (C) NLRP3 with synaptopodin and (D) caspase-1 with synaptopodin in the glomeruli. Data are presented as the mean ± standard deviation (n=3). ***P<0.001 vs. WT control; and ###P<0.001 vs. db/db + vehicle. WT, wild-type mice; Veh, vehicle; AS-IV, Astragaloside IV; NLRP3, NLR family pyrin domain containing 3.