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. 2021 Jun 23;15:696376. doi: 10.3389/fnana.2021.696376

Figure 1.

Figure 1

Differentiation stages of oligodendrocytes in human white matter. (A) Schematic diagram of the oligodendrocyte differentiation process representing the morphology, organelle distribution, and markers to identify each of the three stages: oligodendrocyte precursor cells (OPCs), premyelinating oligodendrocytes (pre-OLs), and mature oligodendrocytes. (B) Human white matter labeled for the astrocytic marker GFAP (red arrow) and the OPC marker NG2 (green arrow) showing that these are two different populations within the white matter of a 39-year-old male (PB4). (C) Human white matter labeled for pre-myelinating oligodendrocyte markers BCAS1/NABC1 and Olig2 co-expressed in highly ramified cells from a 5-year-old female (PB19). (D) Mature oligodendrocytes labeled for Olig2 and APC-(CC1; yellow arrows) from a white matter sample of a 5-year-old female (PB19). (E) Myelin wrapped axons co-expressing MAG and MBP from a white matter sample of a 39-year-old male (PB4). Scale bars: 50 μm.