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. 2021 Jun 14;49(W1):W641–W653. doi: 10.1093/nar/gkab384

Figure 4.

Figure 4.

TIMEOR leverages temporal and multi-omics data to identify a novel gene regulatory network. (A) TIMEOR’s clustermap (25) highlighting TIMEOR’s temporal clustering with observed TFs present in the earliest changing clusters. (B) Validation of predicted TFs using ChIP-seq data provided through TIMEOR to show binding affinity to genes across each cluster. (C) Excerpt of TIMEOR’s Temporal Relations Table showing temporal relationship between TFs. (D) Combining TIMEOR’s Temporal Relations Table, predicted TF information, and STRINGdb (35), TIMEOR outputs a gene regulatory network connecting insulin signaling and the circadian rhythm cycle.