Figure 5.

TIMEOR identifies that insulin acts as a cue for the circadian clock. (A) TIMEOR identifies a GRN comprising both observed and the top predicted TFs binding each cluster (i.e. event order). This causal interaction network (TF GRN) has a subnetwork of previously identified known circadian interactions (see top bracket) (27,30). (B) Schematic showing that TIMEOR found two new players predicted to influence circadian rhythm cycle and are induced by insulin: HNF4, which is known to regulate glucose-dependent insulin secretion, and CG32772, which could regulate the cwo gene.